1. Metamizole-containing medicinal products - referral
They are available under a range of names including Afexil, Algifen, Algifen Neo, Algi-Mabo, Algocalmin ... First published: 14/06/2024 Last updated: 19/07/2024.
EMA recommends measures to minimise serious outcomes of known side effect with painkiller metamizole Product information to be updated to raise awareness of known risk of agranulocytosis and facilitate its early detection and diagnosis On 18 September 2024, the CMDh1 endorsed the measures recommended by EMA’s safety committee, PRAC, to minimise the serious outcomes of agranulocytosis, a known side effect caused by the painkiller metamizole. Agranulocytosis involves a sudden and sharp decrease in granulocytes, a type of white blood cell, that can lead to serious or even fatal infections. Metamizole-containing medicines are authorised in a number of EU countries for treating moderate to severe pain and fever. The authorised uses vary from country to country, ranging from the treatment of pain following surgery or injuries to the treatment of cancer-related pain and fever. Agranulocytosis is a known side effect with metamizole-containing medicines that can occur at any time during treatment or shortly after stopping the medicine, and in people who have used metamizole previously without problems. This serious side effect is not related to the dose of metamizole used. Existing measures in place to minimise this risk vary across countries. The review was started at the request of the Finnish medicines agency, as cases of agranulocytosis were still being reported with metamizole despite the recent strengthening of risk minimisation measures in Finland. After reviewing data on the r...
2. Review of painkiller metamizole started - European Medicines Agency
Jun 14, 2024 · Metamizole (also known as dipyrone) is an analgesic medicine (painkiller). It has been used in the EU since the 1920s and is taken by mouth, ...
Review will look into risk of agranulocytosis, a sudden drop in white blood cells that can lead to serious infections, and measures to minimise it.
3. [PDF] Metamizole A107i_2024-09_public health communication for PRAC
Sep 6, 2024 · The DHPC will also be published on a dedicated page on the EMA website. ... Algocalmin, Algopyrin, Algozone, Alindor, Alkagin, Alvotor, Analgin ...
4. Self-Medication in Rural Northeastern Romania: Patients' Attitudes and ...
Nov 13, 2022 · The differences showed that patients who used Algocalmin had a higher total score on the self-medication scale ( x ¯ = 21.89, SD = 4.38) ...
In recent years, many healthcare systems, along with healthcare professionals, have provided services in a patient-centered manner, in which patients are key actors in the care process. Encouraging self-care creates responsible patients, but it must be ...
5. Algocalmin - Uses, DMF, Dossier, Manufacturer, Supplier, Licensing ...
... 2024-10-07. Virtual Booth. Contact Supplier. ACCESS ALL DATA. Browse all ... published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu) ...
Algocalmin// A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE. Because of the risk of serious adverse effects its use is justified only in serious situations where no alternative is available or suitable. (From Martindale, The Ext...
6. 'They thought I had cancer': painkiller banned in UK linked to Britons ...
Nov 26, 2023 · That report has not been published and there is no comprehensive and robust epidemiological evidence to date to support the theory that British ...
Patients’ group says reactions to metamizole can cause sepsis and organ failure – and British and Irish people are at higher risk
7. Algocalmin | Drug Information, Uses, Side Effects, Chemistry
A drug that has analgesic, anti-inflammatory, and antipyretic properties. It is the sodium sulfonate of AMINOPYRINE.
Technical details about Algocalmin, learn more about the structure, uses, toxicity, action, side effects and more
8. A Case Report on Metamizole-Induced Agranulocytosis
Missing: Algocalmin | Show results with:Algocalmin
Metamizole is a drug with analgesic and antipyretic properties widely available in Portugal. Its use is highly controversial because of the risk of agranulocytosis, a rare but serious adverse event. A 70-year-old female patient with a recent history of ...
9. Pain Medications Under Observation for Dangerous Side Effects
Jun 18, 2024 · The Romanian Medicines Agency has confirmed its participation in the European investigation, which is expected to conclude in September 2024.
The primary concern is the potential for them to cause a rapid decrease in white blood cells.
10. Metamizole versus ibuprofen at home after day surgery: study protocol for ...
... Published: 26 September 2016. Metamizole versus ibuprofen at home after day surgery: study protocol for a ... © 2024 BioMed Central Ltd unless otherwise ...
Postoperative pain and, in a more extended perspective, quality of recovery (QOR) should be considered the principal endpoints after day surgery. Non-steroidal anti-inflammatory drugs (NSAIDs) and paracetamol are a cornerstone of pain treatment after painful day surgery. Nevertheless, NSAIDs are not always sufficiently effective, have numerous contraindications, and consequently are not suitable in up to 25 % of all patients. Metamizole is a non-opioid compound with a favourable gastrointestinal, cardiovascular and cerebrovascular profile compared to NSAIDs. The aim of this study is to assess if a combination of metamizole and paracetamol is non-inferior to a combination of ibuprofen and paracetamol in the treatment of acute postoperative pain at home after painful day case surgery. In addition, we aim to assess and compare quality of recovery (QOR) profiles of both groups. This is an investigator-initiated, double-blind, randomised controlled, non-inferiority trial. A total of 200 patients undergoing elective haemorrhoid surgery, arthroscopic shoulder or knee surgery, or inguinal hernia repair in a day care setting will be randomised to receive either a combination of metamizole and paracetamol (MP) or a combination of ibuprofen and paracetamol (IP). Participants will take study medication orally for 4 days. Primary endpoints are average postoperative pain intensity measured by an 11-point Numeric Rating Scale at postoperative day 1 and QOR profile measured by the...
